T regulatory Function and Modification for Future Application
نویسندگان
چکیده
T regulatory cell is a very particular type of that plays an important role in maintaining homeostasis and peripheral tolerance. The Treg (T cell) CD4+ has many mechanisms to create immune tolerance by effecting B cells. They are for the control tumour immunity, micro biome, organ transplants, allergy course self-tolerance. There also times where Tregs fail whether decrease population, no recognition certain antigens (Inheritance) other reasons such as environmental (theory our system exposed less pathogens modern cities so starts react against own antigens, potential reason increase allergy) but not enough scientific evidence provided yet. can result auto-immune disease apoptotic dermatitis DT1 (diabetes 1). Research about non-cell therapies being researched undergoing clinical trials potentially cure or autoimmune diseases well success rates transplant etc., modifying Tregs.
منابع مشابه
Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes
Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...
متن کاملRegulatory T cells: back to the future.
Regulatory T cells seem to represent the resurrection of the old suppressor T cells. Although of a different phenotype, regulatory T cells are able to suppress many T cell mediated immune responses. While most basic knowledge about these cells is derived from animal studies, the recent identification of these cells in humans has further attributed to their characterisation by in vitro analysis....
متن کاملRegulatory T Cells: Differentiation and Function.
The immune system of vertebrate animals has evolved to mount an effective defense against a diverse set of pathogens while minimizing transient or lasting impairment in tissue function that could result from the inflammation caused by immune responses to infectious agents. In addition, misguided immune responses to "self" and dietary antigens, as well as to commensal microorganisms, can lead to...
متن کاملNotch1 signaling and regulatory T cell function.
Previous studies have shown that the Notch1 and TGF-beta signaling pathways are mutually re-enforcing. Given recent evidence that regulatory T cell (Treg) effector function is mediated by TGF-beta signaling, we investigated whether Notch1 signaling also participated in Treg effector function. Initial studies showed that Notch1 ligands, particularly Jagged1, are present on Tregs and that, indeed...
متن کاملA rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.
Regulatory T cells (CD4(+)CD25(hi)CD127(lo)FOXP3(+) T cells [Tregs]) are a population of lymphocytes involved in the maintenance of self-tolerance. Abnormalities in function or number of Tregs are a feature of autoimmune diseases in humans. The ability to expand functional Tregs ex vivo makes them ideal candidates for autologous cell therapy to treat human autoimmune diseases and to induce tole...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: SHS web of conferences
سال: 2023
ISSN: ['2261-2424', '2416-5182']
DOI: https://doi.org/10.1051/shsconf/202317403006